Antibody Platform

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Bovine Polyclonal Antibody Production Service

KMD Bioscience has been working on producing polyclonal antibodies for many years. We can offer comprehensive polyclonal antibody production services, which involve mouse, rat, rabbit, and other species. Our extensive experience in antibody design and production can ensure customer obtain the custom polyclonal antibody with high quality. Based on upgraded antibody technology, we can offer a reliable and wide range of custom polyclonal antibody production with multiple immunogen options.

Bovine antibodies are structurally unique because of their ultralong CDR3 structure. KMD Bioscience promises to provide high-performance immunoaffinity bovine polyclonal antibody production services and related testing services. Our laboratory has already completed dozens of polyclonal antibody production services for industrial investigators and obtained bovine antibody with neutralizing titers exceeding 1:800,000,000.

 

Bovine Polyclonal Antibody Production:

 

In antibody related research, bovine is a extraordinary source to generate antibodies with exceptionally long CDR3 loops and a few variable regions. Naturally, about 10% of bovine antibodies contain this novel ultralong CDR3 structure, and the size of these antibodies is recognized as the largest among all the antibodies identified. The ultralong CDR3 loops from cattle antibody are the longest (50-61 amino acids) compared with CDR3 loops of other species. Relevant structure and deep sequencing analysis have indicated that the ultralong CDR3 loop has an even number of cysteines, forming a unique architecture in which the cysteines participate in constituting a diversified disulfide-bonded ‘‘knob’’ domain that supported by a β strand ‘‘stalk’’. This long CDR3 loop renders cattle antibody with more efficiency in attacking diverse bacteria and viruses or grabbing onto molecular targets, especially the antigens not recognized by traditional antibodies, such as the GPCRs.

Based on our phage display technology, we are able to provide bovine monoclonal antibody production service. Meanwhile, we can provide a personalized customized protocol, such as peptide design, protein expression requirements and other issues.

 

Service Process:

 

Service Highlights:

 

--Rich experience in polyclonal antibody development

--High affinity and specificity

--High ELISA titer: guaranteed ELISA titer -107 and neutralization titer-108

--Large scale antibody production

--Low background and cross-reactivity

--Broad applicability: antibody pairing, ELISA kit customization

--One-stop services, including antigen preparation, antibody production, antibody purification, antibody modification