Small Molecule Antigen & Antibody Development Service

KMD Bioscience is a professional provider of antibody products and related services for food safety residues and trace levels anylasis. Small molecules, or haptens do not have immunogenic but can induce antibody responses when coupled to carrier proteins. The hapten then reacts specifically with the antibodies generated against it to produce an immune or allergic response. Thus, although the hapten cannot elicit an antibody response on its own, it can bind with carrier and act as an antigen.

Our compound synthesis platform is assisted by professors from Nankai University. After years of practice, we have accumulated rich experiences in small molecule coupling design and antibody production. We can now tailor or synthesize derivatives of small molecule compounds to meet the specific needs of our customers, providing haptens of different tethers, or complete antigens with different carrier proteins. Currently, we can offer monoclonal antibody customization services based on two methods:


*Hybridoma based Antibody Customization Services

*Phage Display Library Technology


Small Molecule Antibody Development Service Workflow:


Carrier Type


Lead time

Hapten Modification


Modified small molecule derivatives

LC-MS result

1-2 weeks

Complete Antigen Production

*Bovine serum albumin (BSA)

*Ovalbumin (OVA)

*Keyhole limpet hemocyanin (KLH)

*Human Serum Albumin (HSA)

*Human gamma globulins

Complete antigen with SDS-PAGE, UV or MALDI-TOF identification results

1-2 weeks

Monoclonal Antibody Production

Antigen emulsification


Cell fusion


Ascites production and antibody purification

Immunoassay results (including ELISA titer and specificity test results)

4-5 months


Applications of Small Molecule Antibodies:

*Rapid and safe detection of small molecule compound

*Food safety testing, such as antibiotics, prohibited additions, drug abuse, etc.

*Disease-related metabolic intermediate detection, blood drug concentration monitoring

*Drug testing, doping control, etc.