Small Molecule Antigen & Antibody Development Service

KMD Bioscience strives to offer high quality antibody production to our customers. The synthesis of small molecule antigen of good immunogenicity is the precondition and an essential matter for monoclonal antibody preparations and making immunoassays strategies. Our scientific staff have extensive expertise in antigen design and antibody development, synthesising the stable artificial small molecule antigen and antibody. With our well-established small molecule platform, we can provide high-quality small molecule antigen & antibody development services.

KMD Bioscience has engaged in small molecule antigen design and synthesis for food safety residue, veterinary drug residue, human or animal diseases diagnosis and trace levels analysis. Based on our capacities in antigen design, our skilled team is glad to tailor reasonable and targeted small molecule modification scheme; in addition, KMD Bioscience provides a wide range of high quality antibody labeling services such as HRP, FITC, BSA, biotin, etc. Meanwhile, we are able to provide one-stop services, including antibody preparation and development of kits.

  

Small Molecule Antigen & Antibody:

 

Small molecules, or haptens do not have immunogenic but can induce antibody responses when coupled to carrier proteins. The hapten then reacts specifically with the antibodies generated against it to produce an immune or allergic response. Thus, although the hapten cannot elicit an antibody response on its own, it can bind with carrier and act as an antigen.

Our compound synthesis platform is assisted by professors from Nankai University. After years of practice, we have accumulated rich experiences in small molecule coupling design and antibody production. We can tailor or synthesize derivatives of small molecule compounds to meet our customers' specific needs, as well as provide haptens of different tethers, or complete antigens with different carrier proteins.

 

Service Content:

 

Packages

Carrier Type

Deliverable

Lead Time

Hapten Modification

/

Modified small molecule derivatives

LC-MS result

1-2 weeks

Complete Antigen Production

*Bovine serum albumin (BSA)

*Ovalbumin (OVA)

*Keyhole limpet hemocyanin (KLH)

*Human Serum Albumin (HSA)

*Human gamma globulins

Complete antigen with SDS-PAGE, UV or MALDI-TOF identification results

1-2 weeks

Monoclonal Antibody Production

Antigen emulsification

Immunization

Cell fusion

Subcloning

Ascites production and antibody purification

Immunoassay results (including ELISA titer and specificity test results)

4-5 months

 

Application:

 

 

Service Highlights:

 

--Rich expertise in small molecule modification and coupling design

--A personalized strategy for antigen design

--High coupling efficiency, shorten the experimental period

--Strict quality control system to ensure reliable results

--Offer multiple antibody labeling and crosslinking service

--One-stop downstream services, including antigen production, antibody development, ELISA kit development, etc