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Antibody Affinity Maturation Services

Affinity maturation is a common strategy to improve an antibody's antigen-binding affinity. In vivo, natural affinity maturation by the immune system takes place by somatic hypermutation and clonal selection. In the laboratory affinity maturation, can be obtained by mutation and selection. KMD Bioscience has extensive experience in antibody affinity maturation. We can provide affinity maturation services for multi-species antibodies based on our own phage antibody library. We are able to make the affinity of monoclonal antibodies reach 10-9M.

 

Antibody Affinity Maturation

Affinity maturation is the process by which Tfh cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. Successive generations of B cells mutate and present to the antigen, that recognize the antigen with high affinity will survive and the low affinity ones are eliminated. KMD Bioscience uses phage display library technology, combined with error-prone PCR and site-directed mutagenesis, we were able to mimic this over-frequency cellular mutations. Our technical advantage lies in the ability to mutate rapidly in vitro and construct more than 1010 independent clones of antibody phage display libraries, so that high specificity and affinity antibodies can be obtained in a short time.

 

Service Highlights:

*Extensive experience: Extensive experience and strong track record in antibody affinity maturation.

*Customizable: Our services are tailored for each project to ensure that the objectives are met or exceeded.

*Guaranteed results: Our clients widely regard us as professional and attentive partners who deliver quality results in a timely manner.