KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
CD278 (Gene ID: 29851) was identified as a member of the CD28/CTLA-4 co-stimulatory molecule family in the early 21st century. Its expression is inducible upon activation of T cells, thus earning it the name "inducible T-cell co-stimulator". CD278 interacts with its ligand, ICOS ligand (ICOS 1 or B7h), and is expressed predominantly on antigen-presenting cells (APCs) such as dendritic cells and B cells. This interaction provides co-stimulatory signals that enhance T cell activation and function.The main functions of CD278 are as follows:
1. T cell activation: CD278 promotes T cell activation by participating in enhanced T cell receptor (TCR) signaling. It leads to increase production of cytokines, including IL-4, IL-10 and IL-21, which are essential for various immune responses.
2. T follicular helper (Tfh) cell differentiation: CD278 is essential for the differentiation and function of Tfh cells, which are critical for providing B cell assistance during the germinal center reaction. The massive expression of CD278 by Tfh cells is essential for the production of high-affinity antibodies.
3. Antibody response: CD278-mediated Tfh cells are essential for facilitating antibody class switching and promoting affinity maturation in B cells. Deficiencies in CD278 or ICOSL lead to impaired antibody response, thereby increasing susceptibility to infection.
4. Regulatory T cell (Treg) stability: CD278 is expressed on Tregs and plays a role in maintaining their stability and suppressive function. Disruption of CD278 signaling can lead to dysregulation of the immune response and autoimmune disease.
5. Immune tolerance: CD278 is associated with immune tolerance and autoimmune prevention. Dysregulation of CD278 signaling may lead to breakdown of immune tolerance mechanisms.
6. Immune-related diseases: The aberrant signaling of CD278 has been associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, highlighting its importance in maintaining immune homeostasis.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality ICOS/CD278 proteins, ICOS/CD278 antibodies and other high-quality target products to research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality ICOS/CD278 related products and promoting the continuous innovation and development of the field of biotechnology.
The featured target ICOS/CD278 protein products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMPH1487 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH3259 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH3260 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1185 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1186 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1356 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
PR368 |
Rat |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5853 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5915 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMH424 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMH427 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMH512 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
MOP2075 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
|
KMH1238 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
MOP2177 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
|
KMH1239 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMP2561 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2562 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2898 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2899 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3689 |
Cynomolgus |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3915 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3916 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3917 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4265 |
Rat |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4266 |
Rat |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4333 |
Rhesus |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4334 |
Rhesus |
HEK293 Cells |
50ug, 100ug, 200ug |
The featured target ICOS/CD278 antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA11541 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
||
|
PA15392 |
Human |
Rabbit |
WB, IHC |
50ul, 100ul |
||
|
MA1216 |
Human |
Rabbit |
WB |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com