KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
The CD274 gene (Gene ID:29126), also known as programmed death ligand 1 (PD-L1) or B7 homologue 1 (B7-H1), is critical in immunoregulatory responses. It encodes a type I transmembrane protein weighing 40 kDa, PD-L1, which plays an important role in suppressing the adaptive immune system during pregnancy, tissue allografts, autoimmune disorders, and hepatitis, among other conditions. PD-L1 was initially characterized as an immunomodulatory molecule in 1999 at the Mayo Clinic. Due to its ability to aid tumor cells in evading antitumor immunity, it has been identified as a cancer-associated factor. PD-L1 interacts with its receptor, PD-1, and is expressed on activated T cells, B cells, and myeloid cells to regulate their activation or suppression. This interaction inhibits T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell proliferation and plays a key role in immune response regulation.
The expression of PD-L1 is influenced by interferons. For example, IFN-γ induces the expression of PD-L1 in a variety of cell types, including T cells, NK cells, macrophages, and epithelial cells. The PD-L1 gene promoter contains a response element for the interferon regulatory factor IRF-1, highlighting the regulation of the gene by immune signaling.
Interestingly, the expression of PD-L1 varies across cell types and under different conditions. For example, it is significantly expressed on macrophages and its expression is influenced by factors such as LPS and interferon-γ. This expression is regulated by components such as STAT1 and can exhibit variability based on the activation status of the macrophage.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD274/PD-L1 proteins, CD274/PD-L1 antibodies and other high-quality targeting products to research institutions, universities and companies. Always adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD274/PD-L1 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target CD274/PD-L1 protein products launched by KMD Bioscience:
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CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMPH1193 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH1194 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH1195 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1030 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1031 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
PM299 |
Cynomolgus |
HEK293 Cells |
100ug, 200ug |
||
|
PM300 |
Cynomolgus |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5881 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5882 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5883 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5884 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5885 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5886 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5887 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5888 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5889 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5890 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5891 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5892 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5929 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5930 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5931 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH6573 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMH423 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
MOP2061 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
|
KMH718 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMH719 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMH1532 |
Human |
Mammalian cells |
50ug, 100ug |
The featured target CD274/PD-L1 antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA5389 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
||
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PA10143 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com