KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
CD40L (Gene ID:959) was initially discovered in the early 1990s as a pivotal molecule involved in B cell activation and immunoglobulin class switching. It is essential for an effective immune response, especially in the context of adaptive immunity. Deficiency of CD40L leads to a severe immunodeficiency disorder known as X-linked hyper-IgM syndrome, which is characterized by impaired antibody production and susceptibility to infections. The gene functions of CD40L are as follow:
1. B cell activation: One of the main functions of CD40L is to activate B cells. When activated T cells with CD40L bind to B cells with CD40, it triggers a series of signaling events within the B cell, leading to its activation, proliferation, and differentiation into an antibody-secreting plasma cell.
2. Immunoglobulin class switching: The interaction between CD40L and CD40 is essential for immunoglobulin class switching, enabling B cells to undergo antibody type conversion (e.g., from IgM to IgG or IgA), which is essential for an effective immune response against different types of pathogens.
3. Formation of germinal centers: CD40L is essential for the establishment and maintenance of germinal centers within lymphoid tissues, which are specialized microenvironments facilitating B cell affinity maturation and subsequent generation of high-affinity antibodies.
4. T cell helper: The CD40L molecule plays a crucial role in facilitating the interaction between T cells and B cells. It ensures that B cells receive the appropriate signals to efficiently produce antibodies. In the absence of CD40L-mediated assistance, the humoral immune response is impaired.
5. Immune memory: CD40L signaling is involved in the development of immunological memory by facilitating the generation of long-term memory B cells and plasma cells, which can provide a rapid and specific immune response when re-exposed to the same pathogen.
6. Autoimmune diseases: Dysregulation of the CD40L-CD40 signaling pathway is associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Abnormal activation of B-cells and antibody production can lead to autoimmunity.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD40LG protein, CD40LG antibody and other high-quality target products for research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD40LG related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target CD40LG protein products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMH327 |
Human |
E. coli |
50ug, 100ug |
||
|
KMH534 |
Human |
E. coli |
50ug, 100ug |
The featured target CD40LG antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA4373 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
||
|
PA6623 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
||
|
MA502 |
Human |
Rabbit |
WB |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com